Imaging Aβ(1–42) fibril elongation reveals strongly polarised growth and growth incompetent states
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چکیده
منابع مشابه
Imaging Aβ(1-42) fibril elongation reveals strongly polarised growth and growth incompetent states.
The major hallmark of Alzheimer's disease is the deposition of plaques of amyloid fibrils formed from amyloid-β (Aβ) peptides. Kinetic studies have contributed significantly towards a mechanistic understanding of amyloid fibril self-assembly, however dynamic features of the aggregation process cannot be captured using ensemble methods. Here we present an assay for imaging Aβ42 aggregation dynam...
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ژورنال
عنوان ژورنال: Phys. Chem. Chem. Phys.
سال: 2017
ISSN: 1463-9076,1463-9084
DOI: 10.1039/c7cp03412a